Synthesis and in vitro antifungal activity of 4-substituted phenylguanidinium salts

Gabriela Braunerová; Vladimír Buchta; Luis Silva; Jirí Kunes; Karel Palát Jr

doi:10.1016/j.farmac.2004.03.001

Synthesis and in vitro antifungal activity of 4-substituted phenylguanidinium salts

Farmaco. 2004 Jun;59(6):443-50. doi: 10.1016/j.farmac.2004.03.001.

Authors

Gabriela Braunerová¹, Vladimír Buchta, Luis Silva, Jirí Kunes, Karel Palát Jr

Affiliation

¹ Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Heyrovského 1203, Hradec Králové 500 05, Czech Republic.

PMID: 15178306
DOI: 10.1016/j.farmac.2004.03.001

Abstract

A series of 4-substituted phenylguanidinium derivatives was synthesized and its antimicrobial activity was evaluated in vitro against eight potentially pathogenic strains of fungi.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / chemical synthesis*
Antifungal Agents / pharmacology
Czech Republic
Drug Evaluation, Preclinical / methods
Fungi / classification
Fungi / drug effects
Guanidines / chemical synthesis*
Guanidines / classification
Guanidines / pharmacology*
Isomerism
Microbial Sensitivity Tests / methods
Models, Chemical

Substances

Antifungal Agents
Guanidines
phenylguanidine