Recurrent calcium nephrolithiasis associated with primary aldosteronism

Am J Kidney Dis. 2004 Jul;44(1):e7-12. doi: 10.1053/j.ajkd.2004.03.037.

Abstract

Typical manifestations of hyperaldosteronism include salt retention, hypokalemia, and metabolic alkalosis. However, a consequence infrequently recognized and described is hypocitraturia. In combination with hypercalciuria, aldosterone-induced hypocitraturia can trigger calcium nephrolithiasis. The authors report a case of an individual with primary hyperaldosteronism from an adrenal adenoma that resulted in hypocitraturia. The patient had severe recurrent renal calcium calculi that corrected with adrenalectomy. The clinical physiology of renal calcium and citrate handling in hyperaldosteronism is reviewed.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adrenal Gland Diseases / complications
  • Adrenal Gland Diseases / diagnostic imaging
  • Adrenal Glands / diagnostic imaging
  • Adrenal Glands / pathology
  • Adrenalectomy
  • Calcium / metabolism
  • Chronic Disease
  • Citrates / metabolism
  • Humans
  • Hyperaldosteronism / complications*
  • Hyperplasia / diagnostic imaging
  • Hypertension / complications
  • Hypokalemia / complications
  • Kidney Calculi / chemistry
  • Kidney Calculi / etiology*
  • Kidney Calculi / prevention & control
  • Male
  • Middle Aged
  • Recurrence
  • Tomography, X-Ray Computed

Substances

  • Citrates
  • Calcium