Rapid and accurate measurement of transverse relaxation times using a single shot multi-echo echo-planar imaging sequence

Magn Reson Imaging. 2004 Sep;22(7):1031-7. doi: 10.1016/j.mri.2004.01.069.

Abstract

Methods for making rapid and accurate measurements and maps of the transverse relaxation time from a single free induction decay (FID) are proposed. The methods use a multi-echo sequence in combination with B1 insensitive (hyperbolic secant or BIREF2b) refocusing pulses and rapid echo-planar imaging techniques. The results were calibrated against a single spin echo echo-planar imaging sequence using a phantom containing a range of CuSO4 concentrations. The mean percentage absolute difference between the multi-echo and single-echo results was 3% for the multi-echo sequence using the hyperbolic secant refocusing pulse, and 7% for the multi-echo sequence using the BIREF2b refocusing pulse, compared to 13% for a multi-echo sequence using a nonselective sinc refocusing pulse. The use of the sequences in vivo has been demonstrated in studies of gastric function, i.e., the measurement of gastric dilution and monitoring of formation of a raft of alginate polysaccharide within the stomach.

MeSH terms

  • Alginates / administration & dosage
  • Aluminum Hydroxide / administration & dosage
  • Antacids / administration & dosage
  • Copper Sulfate
  • Drug Combinations
  • Echo-Planar Imaging / methods*
  • Gastrointestinal Transit / physiology*
  • Humans
  • Phantoms, Imaging
  • Polysaccharides / administration & dosage
  • Silicic Acid / administration & dosage
  • Sodium Bicarbonate / administration & dosage

Substances

  • Alginates
  • Antacids
  • Drug Combinations
  • Polysaccharides
  • Silicic Acid
  • Aluminum Hydroxide
  • alginate, aluminium hydroxide, magnesium trisilicate, sodium bicarbonate drug combination
  • Sodium Bicarbonate
  • Copper Sulfate