Abstract
Putative adhesins were predicted by computer analysis of the Treponema pallidum genome. Two treponemal proteins, Tp0155 and Tp0483, demonstrated specific attachment to fibronectin, blocked bacterial adherence to fibronectin-coated slides, and supported attachment of fibronectin-producing mammalian cells. These results suggest Tp0155 and Tp0483 are fibronectin-binding proteins mediating T. pallidum-host interactions.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adhesins, Bacterial*
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Bacterial Adhesion*
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism*
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Carrier Proteins / genetics
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Carrier Proteins / metabolism*
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Cell Line
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Fibronectins / metabolism*
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Humans
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Recombinant Proteins / genetics
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Recombinant Proteins / metabolism
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Treponema pallidum / pathogenicity
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Treponema pallidum / physiology
Substances
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Adhesins, Bacterial
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Bacterial Proteins
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Carrier Proteins
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Fibronectins
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Recombinant Proteins
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fibronectin-binding proteins, bacterial