Fabrication and properties of a porous chitin/chitosan conduit for nerve regeneration

Yumin Yang; Xiaosong Gu; Renxiang Tan; Wen Hu; Xiaodong Wang; Peiyun Zhang; Tianyi Zhang

doi:10.1007/s10529-004-4611-z

Fabrication and properties of a porous chitin/chitosan conduit for nerve regeneration

Biotechnol Lett. 2004 Dec;26(23):1793-7. doi: 10.1007/s10529-004-4611-z.

Authors

Yumin Yang¹, Xiaosong Gu, Renxiang Tan, Wen Hu, Xiaodong Wang, Peiyun Zhang, Tianyi Zhang

Affiliation

¹ Institute of Functional Biomolecules, State Key Laboratory for Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, PR China. yangym@ntmc.edu.cn

PMID: 15672216
DOI: 10.1007/s10529-004-4611-z

Abstract

A porous, biodegradable, natural chitin/chitosan nerve conduit was constructed. Scanning electron microscopy confirmed that it was homogeneous and highly porous. FT-IR spectra showed that there were no residues arising from the preparation process in the conduit. Addition of chitin to the chitosan solution increased the mechanical strength and maximum tensile strength from 7.2 to 9.6 MPa. Preliminary animal tests indicated that porous chitin/chitosan conduits did not swell in vivo and were compatible with surrounding tissue.

Publication types

Evaluation Study
Research Support, Non-U.S. Gov't

MeSH terms

Absorbable Implants*
Animals
Biocompatible Materials / chemistry*
Chitin / chemistry*
Chitosan / chemistry*
Elasticity
Guided Tissue Regeneration / instrumentation
Guided Tissue Regeneration / methods*
Male
Materials Testing
Nerve Regeneration / physiology*
Porosity
Rats
Rats, Sprague-Dawley
Sciatic Neuropathy / pathology*
Sciatic Neuropathy / surgery*
Surface Properties
Tensile Strength
Treatment Outcome

Substances

Biocompatible Materials
Chitin
Chitosan