Artificial diiron proteins: from structure to function

Biopolymers. 2005;80(2-3):264-78. doi: 10.1002/bip.20230.

Abstract

De novo protein design provides an attractive approach for the construction of models to probe the features required for the function of complex metalloproteins. These minimal models contain the essential elements believed necessary for activity of the protein. In this article, we summarize the design, structure determination, and functional properties of a family of artificial diiron proteins.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Catalytic Domain
  • Dimerization
  • Iron / chemistry
  • Metalloproteins / chemical synthesis
  • Metalloproteins / chemistry*
  • Models, Molecular
  • Molecular Sequence Data
  • Protein Conformation
  • Protein Structure, Quaternary
  • Static Electricity
  • Thermodynamics

Substances

  • Metalloproteins
  • Iron