Localization of the gene for a third G protein beta-subunit to mouse chromosome 6 near Raf-1

Genomics. 1992 Apr;12(4):688-92. doi: 10.1016/0888-7543(92)90295-4.

Abstract

The large family of signal transducing proteins known as G proteins are heterotrimers that dissociate into an independent alpha-subunit and beta gamma-subunit complex after ligand binding or other stimulation. For G alpha, at least 30 distinct sequences representing 10 different classes have been identified. On the other hand, cDNAs for only three G beta-subunit genes have been isolated so far. All three of the G beta genes have been chromosomally mapped in the human, but only two in the mouse. Using a human retinal cDNA for the third G protein beta-subunit, we have mapped the corresponding gene, termed Gnb-3, to mouse Chromosome 6 with somatic cell hybrids and have positioned it distal to but near the marker Raf-1 by analysis of the progeny of three genetic crosses.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chromosome Mapping
  • Cricetinae
  • Crosses, Genetic
  • DNA / genetics
  • GTP-Binding Proteins / chemistry
  • GTP-Binding Proteins / genetics*
  • Genetic Markers
  • Hybrid Cells
  • Mice / genetics*
  • Protein Conformation

Substances

  • Genetic Markers
  • DNA
  • GTP-Binding Proteins