Intrinsic epileptogenicity in polymicrogyric cortex suggested by EEG-fMRI BOLD responses

Neurology. 2005 Apr 12;64(7):1263-6. doi: 10.1212/01.WNL.0000154640.23656.A3.

Abstract

Polymicrogyria (PMG) is a widespread cortical malformation frequently associated with seizures and EEG spikes. Its epileptogenicity is poorly understood. Nine patients with simultaneous EEG and fMRI were studied to assess the blood oxygenation level-dependent response to spikes. Sixteen of 18 studies showed responses, with maximum activation involving the lesion in 61.5%, but often limited to a small fraction of that lesion, suggesting intrinsic epileptogenicity in small areas of the PMG cortex.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / physiology
  • Adult
  • Brain Mapping / methods
  • Cerebral Cortex / abnormalities*
  • Cerebral Cortex / physiopathology*
  • Cerebrovascular Circulation / physiology
  • Electroencephalography / methods*
  • Electroencephalography / trends
  • Epilepsy / diagnosis*
  • Epilepsy / etiology
  • Epilepsy / physiopathology*
  • Female
  • Functional Laterality / physiology
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Magnetic Resonance Imaging / trends
  • Male
  • Nervous System Malformations / complications
  • Nervous System Malformations / diagnosis*
  • Nervous System Malformations / physiopathology*
  • Neural Pathways / abnormalities
  • Neural Pathways / physiopathology
  • Neurons / physiology
  • Predictive Value of Tests