Thirty patients from 3 groups that differed only in the scope of monitoring were examined to study the efficiency of combined neurophysiological and autonomic nervous monitoring in the assess of the quality of anesthesiological protection during highly traumatic surgical interventions made in abdominal patients under combined general anesthesia based on long-term graded epidural naropine (3 mg/ml) infusion at the thoracic level Addition of the Harvard standard with monitoring the information saturation of EEG made it possible to maintain the depth of anesthesia, by reducing the dose of dormicum by 20% (p < 0.05). The use of combined monitoring of EEG information saturation and the tension index after R. M. Bayevsky could reduce the dose of fentanyl by 2.3-2.7 times (p < 0.05) and the incidence of critical cardiovascular incidents by 39% (p < 0.05).