The usefulness of single nucleotide polymorphisms (SNPs) for genetic epidemiological investigation of complex psychiatric diseases

Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jul;29(6):1017-20. doi: 10.1016/j.pnpbp.2005.03.018.

Abstract

The genetic epidemiology of complex psychiatric diseases has become a much studied and very prospering field. It is widely believed that many genetic factors contribute to the various phenotypes and diseases, with overall contributions of a single factor being comparatively minor. The study of choice in such settings is the investigation of allelic association, which may be performed in a variety of ways. Here single nucleotide polymorphisms are an indispensable tool.

Publication types

  • Review

MeSH terms

  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Humans
  • Mental Disorders / epidemiology
  • Mental Disorders / genetics*
  • Phenotype
  • Polymorphism, Single Nucleotide*
  • Risk