Chlorination of 3beta-hydroxyl-5-Delta steroids with anhydrous ferric chloride

Steroids. 2005 Nov;70(12):825-30. doi: 10.1016/j.steroids.2005.04.008.

Abstract

Treatment of 3beta-hydroxyl-5-Delta steroids with anhydrous FeCl(3) in CH(2)Cl(2) afforded reasonable yields of the corresponding alkyl chlorides with a retention of configurations. The structures of the chlorine-exchanging products were determined by NMR and HRMS spectra. The absolute configurations were confirmed by X-ray crystal analysis of 3beta-chloro-androst-5-en-17-one. The generality and scope of the reaction were also investigated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chlorides
  • Ferric Compounds / chemistry*
  • Hydroxysteroids / chemistry*
  • Magnetic Resonance Spectroscopy / methods
  • Molecular Structure

Substances

  • Chlorides
  • Ferric Compounds
  • Hydroxysteroids
  • ferric chloride