Abstract
Fifteen participants of the Antarctic expedition (men, 27-51 years old) have been investigated after their return from a one-year stay there. All subjects have signs of latent hypoxia. Compensation of hypoxic reactions depended on the initial state of organism oxygen regimen as well as on the features of a genotype. It was supposed that, after a long stay by a person in the coastal Antarctic conditions, the latent form of hypoxia could develop. The latter was accompanied by reorganizations of oxygen regimen and determined by specific features of a genotype.
MeSH terms
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Adaptation, Physiological / genetics
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Adaptation, Physiological / physiology*
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Adult
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Antarctic Regions
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Blood Volume / physiology
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DNA-Binding Proteins / genetics
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Exercise Test
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Genotype
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Hemodynamics / physiology
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Humans
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Hypoxia / blood
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Hypoxia / physiopathology*
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Hypoxia-Inducible Factor 1
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Hypoxia-Inducible Factor 1, alpha Subunit
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Male
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Middle Aged
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Nuclear Proteins / genetics
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Oxidative Stress / physiology
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Oxygen / blood*
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Polymorphism, Genetic
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Pulmonary Gas Exchange / physiology*
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Transcription Factors / genetics
Substances
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DNA-Binding Proteins
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HIF1A protein, human
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Hypoxia-Inducible Factor 1
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Hypoxia-Inducible Factor 1, alpha Subunit
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Nuclear Proteins
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Transcription Factors
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Oxygen