Dynamic pattern of mRNA expression of plasticity-related gene-3 (PRG-3) in the mouse cerebral cortex during development

Brain Res Bull. 2005 Sep 15;66(4-6):454-60. doi: 10.1016/j.brainresbull.2005.05.010.

Abstract

Intrinsic genetic differences and extrinsic influences both contribute to the formation of functional and anatomical areas within the mammalian cerebral cortex. Using subtractive hybridisation and differential screening, we demonstrated that plasticity-related gene-3 (PRG-3) is differentially expressed between the dorsal and lateral cortex at P6. PRG-3 is one of the key enzymes that are involved in the metabolism of phospholipids, such as LPA and S1P, in the nervous system. Here, for the first time, we report the mRNA expression pattern of PRG-3 in the developing and adult mouse cerebral cortex.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Animals
  • Animals, Newborn
  • Blotting, Southern / methods
  • Cerebral Cortex / embryology
  • Cerebral Cortex / growth & development
  • Cerebral Cortex / metabolism*
  • Cloning, Molecular / methods
  • Embryo, Mammalian
  • Eosinophil Major Basic Protein / genetics
  • Eosinophil Major Basic Protein / metabolism*
  • Gene Expression
  • Gene Expression Regulation, Developmental / physiology*
  • In Situ Hybridization / methods
  • Mice
  • Mice, Inbred C57BL
  • RNA, Messenger / metabolism

Substances

  • Prg3 protein, mouse
  • RNA, Messenger
  • Eosinophil Major Basic Protein