Temporal characteristics of tactile stimuli influence the response profile of cerebellar Golgi cells

Neurosci Lett. 2005 Dec 30;390(3):156-61. doi: 10.1016/j.neulet.2005.08.018. Epub 2005 Sep 12.

Abstract

An increasing number of studies have investigated the effect of stimulation parameters on neuronal response properties. Here, we describe the effect of temporal characteristics of tactile stimuli, more specifically the stimulation frequency and duration, on the response profile of simultaneously recorded cerebellar and cerebral cortical units in ketamine-xylazine anaesthetized rats. Long stimulus durations (>50 ms) elicited ON and OFF excitatory components in response to the stimulus onset and offset respectively, in both the cortex and the cerebellum. Golgi cells responded on average 7.5 ms later to the stimulus withdrawal than to the stimulus onset. Furthermore, the corticopontine OFF responses in the cerebellum and OFF responses in the cortex showed congruent latency decreases and amplitude increases for longer stimulus durations (50-200 ms). Decreasing the stimulus frequency similarly affected the latency and amplitude of the responses for inter-stimuli intervals shorter than 200 ms. In view of these results, we speculate that the stimulus offset is regarded as a novel input, because both paradigms resulted in similar response amplitude and latency modifications. Finally, the results suggest that a 100-200 ms time window can be of particular importance for cerebellar processing of information in the somatosensory system.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / physiology*
  • Animals
  • Cerebellum / cytology*
  • Male
  • Neural Inhibition / physiology
  • Neurons / physiology*
  • Physical Stimulation / methods
  • Rats
  • Rats, Sprague-Dawley
  • Reaction Time / physiology*
  • Time Factors