A new SUMO ligase in the DNA damage response

DNA Repair (Amst). 2006 Jan 5;5(1):138-41. doi: 10.1016/j.dnarep.2005.08.003. Epub 2005 Sep 27.

Abstract

SUMO is a small ubiquitin-like protein that is attached to target proteins, altering their localization and function. The condensin and cohesin-related Smc5/6 complex has been linked to DNA repair and checkpoint responses, but details of its molecular function have remained obscure. Recent reports show one subunit of the complex is a SUMO ligase, providing another link between protein sumoylation and DNA damage responses.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism
  • Chromosomal Proteins, Non-Histone / genetics
  • Chromosomal Proteins, Non-Histone / metabolism
  • DNA Damage*
  • DNA Repair*
  • SUMO-1 Protein / physiology*
  • Saccharomyces cerevisiae Proteins / genetics
  • Saccharomyces cerevisiae Proteins / metabolism
  • Schizosaccharomyces pombe Proteins / genetics
  • Schizosaccharomyces pombe Proteins / metabolism
  • Species Specificity

Substances

  • Cell Cycle Proteins
  • Chromosomal Proteins, Non-Histone
  • SMC5 protein, S cerevisiae
  • SMC6 protein, S cerevisiae
  • SUMO-1 Protein
  • Saccharomyces cerevisiae Proteins
  • Schizosaccharomyces pombe Proteins
  • Smc5 protein, S pombe
  • smc6 protein, S pombe