Abstract
SUMO is a small ubiquitin-like protein that is attached to target proteins, altering their localization and function. The condensin and cohesin-related Smc5/6 complex has been linked to DNA repair and checkpoint responses, but details of its molecular function have remained obscure. Recent reports show one subunit of the complex is a SUMO ligase, providing another link between protein sumoylation and DNA damage responses.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Cell Cycle Proteins / genetics
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Cell Cycle Proteins / metabolism
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Chromosomal Proteins, Non-Histone / genetics
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Chromosomal Proteins, Non-Histone / metabolism
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DNA Damage*
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DNA Repair*
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SUMO-1 Protein / physiology*
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Saccharomyces cerevisiae Proteins / genetics
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Saccharomyces cerevisiae Proteins / metabolism
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Schizosaccharomyces pombe Proteins / genetics
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Schizosaccharomyces pombe Proteins / metabolism
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Species Specificity
Substances
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Cell Cycle Proteins
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Chromosomal Proteins, Non-Histone
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SMC5 protein, S cerevisiae
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SMC6 protein, S cerevisiae
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SUMO-1 Protein
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Saccharomyces cerevisiae Proteins
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Schizosaccharomyces pombe Proteins
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Smc5 protein, S pombe
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smc6 protein, S pombe