A new notch in the HIF belt: how hypoxia impacts differentiation

Dev Cell. 2005 Nov;9(5):575-6. doi: 10.1016/j.devcel.2005.10.001.

Abstract

In the current issue of Developmental Cell, work by Gustafsson and coworkers demonstrates that hypoxia synergizes with Notch to inhibit differentiation of myogenic and neural precursor cells. This effect requires a newly described interaction between the transcriptionally active form of HIF-1alpha and the intracellular domain of Notch.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Carbamates / pharmacology
  • Cell Differentiation / drug effects
  • Cell Differentiation / physiology*
  • Dipeptides / pharmacology
  • Hypoxia / metabolism*
  • Hypoxia-Inducible Factor 1, alpha Subunit / metabolism*
  • Myoblasts / cytology
  • Myoblasts / drug effects
  • Myoblasts / metabolism
  • Receptors, Notch / drug effects
  • Receptors, Notch / metabolism*
  • Stem Cells / cytology
  • Stem Cells / drug effects
  • Stem Cells / metabolism

Substances

  • Carbamates
  • Dipeptides
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • L 685458
  • Receptors, Notch