The 3p21.1-p21.3 hereditary vascular retinopathy locus increases the risk for Raynaud's phenomenon and migraine

Cephalalgia. 2005 Dec;25(12):1168-72. doi: 10.1111/j.1468-2982.2005.00994.x.

Abstract

Previously, we described a large Dutch family with hereditary vascular retinopathy (HVR), Raynaud's phenomenon and migraine. A locus for HVR was mapped on chromosome 3p21.1-p21.3, but the gene has not yet been identified. The fact that all three disorders share a vascular aetiology prompted us to study whether the HVR haplotype also contributed to Raynaud's phenomenon and migraine in this family. Whereas the parent-child transmission disequilibrium test (TDT) did not reach significance, the sibling TDT revealed that the HVR haplotype harbours a susceptibility factor for Raynaud's phenomenon and migraine. Identification of the HVR gene will improve the understanding of the pathophysiology of HVR, Raynaud's phenomenon and migraine.

Publication types

  • Clinical Trial, Phase I
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Comorbidity
  • Female
  • Genes, Dominant
  • Genetic Predisposition to Disease / epidemiology
  • Genetic Predisposition to Disease / genetics
  • Haplotypes
  • Humans
  • Male
  • Migraine Disorders / epidemiology*
  • Migraine Disorders / genetics*
  • Netherlands / epidemiology
  • Phenotype
  • Prevalence
  • Quantitative Trait Loci / genetics
  • Quantitative Trait, Heritable
  • Raynaud Disease / epidemiology*
  • Raynaud Disease / genetics*
  • Retinal Diseases / epidemiology*
  • Retinal Diseases / genetics*
  • Risk Assessment / methods*
  • Sequence Analysis, DNA