Proteomic analysis of the CSF in unmedicated patients with major depressive disorder reveals alterations in suicide attempters

Eur Arch Psychiatry Clin Neurosci. 2005 Dec;255(6):438-40. doi: 10.1007/s00406-005-0575-9.

Abstract

This is the first report on proteomic analysis of the cerebrospinal fluid (CSF) in unmedicated suicide attempters and non-attempters with major depressive disorder. Two-dimensional (2D) gel electrophoresis revealed that suicide attempters differed from non-attempters in one protein with an approximate molecular weight of 33 kD and an isoelectric point of 5.2. Proteomic analysis of the CSF is a promising non hypothesis-driven screening method for the detection of new candidate genes in neurobiological suicide research.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cerebrospinal Fluid Proteins / chemistry*
  • Depressive Disorder, Major / cerebrospinal fluid*
  • Depressive Disorder, Major / psychology*
  • Electrophoresis, Gel, Two-Dimensional
  • Female
  • Humans
  • Isoelectric Focusing
  • Male
  • Middle Aged
  • Proteomics*
  • Psychiatric Status Rating Scales
  • Suicide, Attempted / psychology*

Substances

  • Cerebrospinal Fluid Proteins