Family specific rates of protein evolution

Bioinformatics. 2006 May 15;22(10):1166-71. doi: 10.1093/bioinformatics/btl073. Epub 2006 Mar 1.

Abstract

Motivation: Amino acid changing mutations in proteins are contstrained by purifying selection and accumulate at different rates. We estimate evolutionary rates on multiple alignments of eukaryotic protein families in a maximum likelihood framework and spot sets of slow and fast evolving proteins.

Results: We find that the evolution of indispensable proteins is constrained by selection and that protein secretion is coupled to an increased evolutionary rate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Amino Acid Sequence
  • Animals
  • Computer Simulation
  • Conserved Sequence
  • Evolution, Molecular*
  • Humans
  • Models, Genetic*
  • Molecular Sequence Data
  • Proteome / classification
  • Proteome / genetics*
  • Proteome / metabolism*
  • Sequence Alignment / methods*
  • Sequence Analysis, Protein / methods*
  • Sequence Homology, Amino Acid
  • Species Specificity

Substances

  • Proteome