ESCRT complexes assembled and GLUEd

Sudharshan Eathiraj; David G Lambright

doi:10.1016/j.str.2006.03.005

ESCRT complexes assembled and GLUEd

Structure. 2006 Apr;14(4):631-2. doi: 10.1016/j.str.2006.03.005.

Authors

Sudharshan Eathiraj, David G Lambright

PMID: 16615903
DOI: 10.1016/j.str.2006.03.005

Abstract

The ESCRT-I, -II, and -III complexes act sequentially to sort monoubiquitinated transmembrane proteins into multivesicular bodies for targeted degradation in the lysosome. Two papers published in a recent issue of Cell provide insights into the structural organization and functional interactions of the ESCRT-I complex and ESCRT-II GLUE domain.

Publication types

News

MeSH terms

Animals
Cell Membrane / metabolism
Endosomes / chemistry
Endosomes / metabolism*
Lysosomes / metabolism
Models, Biological
Models, Genetic
Models, Molecular
Molecular Conformation
Phosphatidylinositol Phosphates / chemistry
Protein Binding
Protein Conformation
Protein Structure, Tertiary
Protein Transport
Ubiquitin / chemistry

Substances

Phosphatidylinositol Phosphates
Ubiquitin
phosphatidylinositol 3-phosphate