ANCA-associated diffuse alveolar hemorrhage due to benzylthiouracil

Eur J Pediatr. 2006 Jul;165(7):435-6. doi: 10.1007/s00431-005-0053-4. Epub 2006 Apr 19.

Abstract

Benzylthiouracil has been recently observed to be associated with antineutrophil cytoplasmic antibody-positive vasculitis, resulting in crescentic glomerulonephritis. We report an 8-year-old girl treated with benzylthiouracil for Graves's disease who developed an ANCA-positive vasculitis with pulmonary hemorrhage. She responded to corticosteroids and discontinuation of benzylthiouracil. This represents the first pediatric case of benzylthiouracil-induced diffuse alveolar hemorrhage.

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Antineutrophil Cytoplasmic / immunology*
  • Child
  • Female
  • Graves Disease / drug therapy
  • Hemorrhage / chemically induced*
  • Hemorrhage / immunology
  • Humans
  • Lung Diseases / chemically induced*
  • Lung Diseases / immunology
  • Thiouracil / adverse effects
  • Thiouracil / analogs & derivatives*
  • Thiouracil / therapeutic use
  • Vasculitis / chemically induced*
  • Vasculitis / immunology

Substances

  • Antibodies, Antineutrophil Cytoplasmic
  • Thiouracil
  • benzylthiouracil