Active Denial Systems (ADS) is a millimetric wave radiation emitting technology now included in the non lethal weapon arsenal. Such devices emit electromagnetic, thus agitating water in the skin and causing feeling of heat enough that target individual retreats from the beam. They can be used at up to 1 km from the target. We have reviewed the literature on the interactions of millimetric waves (MMW) with biological systems. An opposition appears between the observations performed in the Former Soviet Union and Russia showing potential interaction sometimes deleterious while generally of good influence and used in therapy. By way of contrast, most of the other studies, performed in USA, address local acute effects, exclusively located on the skin and eyes of the target, and considered as completely reversible.