In vivo 13C NMR spectroscopy and metabolic modeling in the brain: a practical perspective

Pierre-Gilles Henry; Gregor Adriany; Dinesh Deelchand; Rolf Gruetter; Malgorzata Marjanska; Gülin Oz; Elizabeth R Seaquist; Alexander Shestov; Kâmil Uğurbil

doi:10.1016/j.mri.2006.01.003

In vivo 13C NMR spectroscopy and metabolic modeling in the brain: a practical perspective

Magn Reson Imaging. 2006 May;24(4):527-39. doi: 10.1016/j.mri.2006.01.003. Epub 2006 Feb 20.

Authors

Pierre-Gilles Henry¹, Gregor Adriany, Dinesh Deelchand, Rolf Gruetter, Malgorzata Marjanska, Gülin Oz, Elizabeth R Seaquist, Alexander Shestov, Kâmil Uğurbil

Affiliation

¹ Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN 55455, USA. henry@cmrr.umn.edu

PMID: 16677959
DOI: 10.1016/j.mri.2006.01.003

Abstract

In vivo 13C NMR spectroscopy has the unique capability to measure metabolic fluxes noninvasively in the brain. Quantitative measurements of metabolic fluxes require analysis of the 13C labeling time courses obtained experimentally with a metabolic model. The present work reviews the ingredients necessary for a dynamic metabolic modeling study, with particular emphasis on practical issues.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain / metabolism*
Carbon Radioisotopes
Magnetic Resonance Spectroscopy*
Models, Biological
Rats

Substances

Carbon Radioisotopes

Abstract

Publication types

MeSH terms

Substances

Grants and funding