Aerobic intramolecular oxidative amination of alkenes catalyzed by NHC-coordinated palladium complexes

Org Lett. 2006 May 25;8(11):2257-60. doi: 10.1021/ol060327q.

Abstract

[reaction: see text] Palladium(II) complexes bearing a single N-heterocyclic carbene ligand serve as effective catalysts for the aerobic oxidative cyclization of alkenes with pendant sulfonamides. The use of carboxylic acid cocatalysts (AcOH and PhCO(2)H) often leads to significant improvements in catalyst stability and product yield and enables catalytic turnover to be achieved with air, rather than pure oxygen gas, as the source of O(2).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry*
  • Amination
  • Carboxylic Acids / chemistry
  • Catalysis
  • Cyclization
  • Molecular Structure
  • Oxidation-Reduction
  • Oxygen / chemistry
  • Palladium / chemistry*

Substances

  • Alkenes
  • Carboxylic Acids
  • Palladium
  • Oxygen