Dry eye after photorefractive keratectomy with adjuvant mitomycin C

J Refract Surg. 2006 May;22(5):511-3. doi: 10.3928/1081-597X-20060501-16.

Abstract

Purpose: To report a patient with dry eye after bilateral photorefractive keratectomy (PRK) with mitomycin C treatment in one eye.

Methods: A 29-year-old woman underwent PRK for moderate myopia. The left eye was randomly assigned and intraoperative topical mitomycin C was administered. The right (control) eye was treated with intraoperative corticosteroid only.

Results: The patient developed dry eye symptoms and superficial punctuate keratopathy in the eye treated with mitomycin C. Fifteen months after surgery no improvement was noted.

Conclusions: Photorefractive keratectomy with mitomycin C treatment could induce or exacerbate dry eye.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Dry Eye Syndromes / etiology*
  • Female
  • Glucocorticoids / administration & dosage
  • Humans
  • Intraoperative Period
  • Lasers, Excimer
  • Mitomycin / administration & dosage
  • Mitomycin / adverse effects*
  • Nucleic Acid Synthesis Inhibitors / administration & dosage
  • Nucleic Acid Synthesis Inhibitors / adverse effects*
  • Ophthalmic Solutions
  • Photorefractive Keratectomy / adverse effects*
  • Postoperative Complications / prevention & control
  • Risk Factors

Substances

  • Glucocorticoids
  • Nucleic Acid Synthesis Inhibitors
  • Ophthalmic Solutions
  • Mitomycin