Induction of graft acceptance after dog kidney or liver transplantation

Transplant Proc. 1990 Feb;22(1):80-2.

Abstract

We have reported that, a short delayed course of intramuscular FK 506 can induce a,donor strain-specific immunologic unresponsiveness to cardiac allograft in rats. Further studies have been performed to determine if this agent can induce graft acceptance after canine renal (KT) or hepatic (OLT) allotransplantation. Preliminary descriptions of these efforts have been published.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / administration & dosage*
  • Dogs
  • Female
  • Graft Survival / drug effects
  • Immunity, Cellular / drug effects
  • Immunosuppressive Agents / administration & dosage*
  • Injections, Intramuscular
  • Kidney Transplantation / immunology*
  • Liver Transplantation / immunology*
  • Lymphocyte Culture Test, Mixed
  • Tacrolimus

Substances

  • Anti-Bacterial Agents
  • Immunosuppressive Agents
  • Tacrolimus