Ceramide causes pulmonary cell apoptosis and emphysema: a role for sphingolipid homeostasis in the maintenance of alveolar cells

Proc Am Thorac Soc. 2006 Aug;3(6):510. doi: 10.1513/pats.200603-071MS.

Authors

Irina Petrache¹, Viswanathan Natarajan, Lijie Zhen, Terry R Medler, Amy Richter, Evgeni V Berdyshev, Rubin M Tuder

Affiliation

¹ Division of Pulmonary, Allergy, Critical Care and Occupational Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA. ipetrach@iupui.edu

PMID: 16921130
DOI: 10.1513/pats.200603-071MS

No abstract available

MeSH terms

Animals
Apoptosis*
Ceramides / biosynthesis*
Humans
Mice
Pulmonary Alveoli / metabolism
Pulmonary Alveoli / pathology*
Pulmonary Emphysema / metabolism
Pulmonary Emphysema / pathology*
Rats
Smoking / adverse effects
Smoking / metabolism
Sphingolipids / metabolism*
Up-Regulation*

Substances

Ceramides
Sphingolipids