Level of cognitive impairment predicts mortality in high-risk community samples: the memory and medical care study

J Neuropsychiatry Clin Neurosci. 2006 Fall;18(4):543-6. doi: 10.1176/jnp.2006.18.4.543.

Abstract

Over the course of 3 years, the authors investigated the relationship between severity of cognitive impairment and mortality in a community sample of 498 elders at high risk for cognitive impairment. Subjects were classified as having no cognitive disorder, mild cognitive impairment, or dementia, based on a validated battery of four neuropsychological tests. Severity of impairment was based on Mini-Mental State Examination scores. Additional data were obtained from subjects' knowledgeable informants and Medicare records. Kaplan-Meier survival estimates and Cox hazard proportion analysis of the sample revealed that presence of cognitive impairment increases mortality in a fashion that parallels the severity of the impairment.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Aged, 80 and over
  • Cognition Disorders / epidemiology*
  • Cognition Disorders / mortality
  • Cognition Disorders / physiopathology*
  • Dementia / mortality
  • Dementia / physiopathology*
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Medicare / statistics & numerical data
  • Memory / physiology*
  • Mental Status Schedule / statistics & numerical data
  • Neuropsychological Tests / statistics & numerical data
  • Proportional Hazards Models
  • Residence Characteristics*
  • Retrospective Studies