Chemical crosshairs on the central dogma

Nat Chem Biol. 2007 Jan;3(1):2-7. doi: 10.1038/nchembio0107-2.

Abstract

As cellular machines and processes that regulate the flow of genomic information have come into sharper focus, a new level of chemical control has become possible. The scope of such chemical intervention extends from the mechanistic dissection of biochemical processes in living cells to the targeted control of gene networks and cell fate.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / metabolism
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Ligands
  • Models, Biological
  • Models, Molecular
  • Molecular Structure
  • RNA Interference / drug effects
  • RNA Interference / physiology
  • RNA Polymerase II / antagonists & inhibitors
  • RNA Polymerase II / chemistry*
  • RNA Polymerase II / metabolism
  • RNA Polymerase II / physiology*
  • Transcription, Genetic*

Substances

  • Enzyme Inhibitors
  • Ligands
  • RNA Polymerase II