Signaling netwErks get the global treatment

Michael B Yaffe; Forest M White

doi:10.1186/gb-2007-8-1-202

Signaling netwErks get the global treatment

Genome Biol. 2007;8(1):202. doi: 10.1186/gb-2007-8-1-202.

Authors

Michael B Yaffe¹, Forest M White

Affiliation

¹ Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. myaffe@mit.edu

Abstract

Two landmark studies of cell signaling, by RNA interference and phosphoproteomics, provide complementary global views of the pathways downstream of receptor kinases, including those regulated by Erks.

MeSH terms

Animals
Enzyme Activation
Extracellular Signal-Regulated MAP Kinases / metabolism*
Proteomics
RNA Interference
Receptor Protein-Tyrosine Kinases / metabolism
Signal Transduction*

Substances

Receptor Protein-Tyrosine Kinases
Extracellular Signal-Regulated MAP Kinases