Microwave-assisted RCM for the synthesis of carbocyclic peptides

J Pept Sci. 2007 Apr;13(4):280-5. doi: 10.1002/psc.840.

Abstract

Microwave irradiation dramatically improves the efficiency of ring closing metathesis (RCM) reactions of resin-attached peptides and the technology is illustrated by the highly selective synthesis of dicarba analogues of alpha-conotoxin IMI.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acids, Carbocyclic / chemistry
  • Biochemistry / methods*
  • Microwaves
  • Peptides / chemical synthesis*

Substances

  • Acids, Carbocyclic
  • Peptides