[Quantitative methylation-specific PCR for the diagnosis of lung cancer]

Pathologe. 2007 Sep;28(5):377-83. doi: 10.1007/s00292-007-0929-3.
[Article in German]

Abstract

Efficient, preferably early diagnosis of lung cancer represents a major challenge. Under this aspect the sensitivity of conventional histomorphology and cytomorphology procedures is unsatisfactory. This review highlights technical aspects, possibilities and drawbacks of the application of aberrant promoter methylation as a biomarker for lung cancer diagnostics using specimens of pulmonary exfoliative cytology.

Publication types

  • English Abstract

MeSH terms

  • DNA Methylation*
  • Genetic Markers
  • Humans
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / pathology*
  • Polymerase Chain Reaction / methods*
  • Promoter Regions, Genetic
  • Sensitivity and Specificity

Substances

  • Genetic Markers