Percutaneous transluminal coronary angioplasty (PTCA) is a widely used technique of myocardial revascularization. The number of patients treated by PTCA is continuously growing in spite of its major drawback, represented by restenosis in approximately 30% of patients. We report here the case of a PTCA performed on a tight left anterior descending lesion in the presence of a muscular bridge involving the stenotic area. The procedure was completely successful by both the angiographic and clinical side. Good patency of the vessel with nearly complete disappearance of the lesion was confirmed at 6-month angiographic follow-up. In conclusion, the presence of a muscular bridge involving the stenotic area does not seem to represent a contraindication to PTCA.