Antibiotic resistance and single-nucleotide polymorphism cluster grouping type in a multinational sample of resistant Mycobacterium tuberculosis isolates

Antimicrob Agents Chemother. 2007 Nov;51(11):4157-9. doi: 10.1128/AAC.00619-07. Epub 2007 Sep 10.

Abstract

A single-nucleotide polymorphism-based cluster grouping (SCG) classification system for Mycobacterium tuberculosis was used to examine antibiotic resistance type and resistance mutations in relationship to specific evolutionary lineages. Drug resistance and resistance mutations were seen across all SCGs. SCG-2 had higher proportions of katG codon 315 mutations and resistance to four drugs.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Bacterial Proteins / genetics
  • Bacterial Typing Techniques / methods
  • Catalase / genetics
  • Drug Resistance, Microbial / genetics*
  • Microbial Sensitivity Tests
  • Mycobacterium tuberculosis / classification
  • Mycobacterium tuberculosis / drug effects*
  • Mycobacterium tuberculosis / genetics*
  • Polymorphism, Single Nucleotide*

Substances

  • Bacterial Proteins
  • Catalase
  • katG protein, Mycobacterium tuberculosis