Fatal hypertensive crisis as presentation of mitochondrial complex I deficiency

Neuropediatrics. 2007 Jun;38(3):148-50. doi: 10.1055/s-2007-985903.

Abstract

Complex I deficiency is a frequent defect of the mitochondrial electron transport chain. We report on a 3-year-old boy, who rapidly deteriorated after sudden flushing and collapse. This fatal and unusual case was characterized by widely uncontrollable arterial hypertension. It might indicate that hypertensive crisis could be a potential manifestation of mitochondrial disorders.

Publication types

  • Case Reports

MeSH terms

  • Antihypertensive Agents / therapeutic use
  • Blood Pressure / physiology
  • Cerebral Cortex / pathology*
  • Child, Preschool
  • Electron Transport Complex I / deficiency*
  • Humans
  • Hypertensive Encephalopathy / drug therapy
  • Hypertensive Encephalopathy / etiology*
  • Hypertensive Encephalopathy / pathology*
  • Male
  • Mitochondrial Diseases / complications*
  • Mitochondrial Diseases / enzymology
  • Mitochondrial Diseases / pathology

Substances

  • Antihypertensive Agents
  • Electron Transport Complex I