Imaging obesity: fMRI, food reward, and feeding

Harvey J Grill; Karolina P Skibicka; Matthew R Hayes

doi:10.1016/j.cmet.2007.11.007

Imaging obesity: fMRI, food reward, and feeding

Cell Metab. 2007 Dec;6(6):423-5. doi: 10.1016/j.cmet.2007.11.007.

Authors

Harvey J Grill¹, Karolina P Skibicka, Matthew R Hayes

Affiliation

¹ Graduate Group of Psychology and Graduate Group of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA. grill@psych.upenn.edu

PMID: 18054310
DOI: 10.1016/j.cmet.2007.11.007

Abstract

Animal studies have revealed brain regions that control homeostatic feeding, but the rampant overeating contributing to the obesity epidemic suggests the participation of "nonhomeostatic" control centers. Recent papers by Batterham et al. (2007) and Farooqi et al. (2007) link peptide YY(3-36) and leptin to the activation of nonhomeostatic brain regions.

Publication types

Comment

MeSH terms

Animals
Brain / physiology
Eating / physiology
Food
Homeostasis
Humans
Leptin / physiology
Magnetic Resonance Imaging
Models, Neurological
Obesity / physiopathology*
Obesity / psychology
Peptide Fragments
Peptide YY / physiology
Reward

Substances

Leptin
Peptide Fragments
Peptide YY
peptide YY (3-36)