Moderate reduction of gamma-secretase: is there a therapeutic sweet spot?

J Neurosci. 2007 Dec 12;27(50):13579-80. doi: 10.1523/JNEUROSCI.4821-07.2007.

Authors

Se Hoon Choi¹, Eric Norstrom

Affiliation

¹ Committee on Neurobiology, University of Chicago, Chicago, Illinois 60637, USA.

No abstract available

Publication types

Comment

MeSH terms

Alzheimer Disease / genetics*
Alzheimer Disease / metabolism*
Alzheimer Disease / therapy
Amyloid Precursor Protein Secretases / genetics*
Amyloid Precursor Protein Secretases / metabolism*
Amyloid beta-Peptides / metabolism*
Animals
Brain / metabolism
Carcinoma, Squamous Cell / genetics*
Carcinoma, Squamous Cell / prevention & control
Cells, Cultured
Crosses, Genetic
Disease Models, Animal
Disease Progression
Fibroblasts / metabolism
Gene Expression Regulation / genetics
Humans
Mice
Mice, Transgenic
Skin Neoplasms / genetics*
Skin Neoplasms / prevention & control
Splenomegaly / genetics
Splenomegaly / prevention & control
Survival Rate

Substances

Amyloid beta-Peptides
Amyloid Precursor Protein Secretases