Resistant hypertension has a high prevalence and is associated with high morbidity and mortality. The Rheos Baroreflex Hypertension Therapy System is an implantable device that offers a completely new approach to treating patients with resistant hypertension by electrically activating the carotid baroreflex. Preliminary results from current feasibility clinical trials have shown sustained decreases in blood pressure after 1 year. The pivotal trial for US FDA approval and market release is currently ongoing. This article profiles the Rheos System and evaluates the treatment of resistant hypertension in general.