Study of manganese bacteriopheophorbide as a potential contrast agent for magnetic resonance tomography

I G Meerovich; A Brandis; G A Meerovich; A A Stratonnikov; P Bendel; N A Oborotova; A Shertz; A Yu Baryshnikov

doi:10.1007/s10517-007-0154-3

Study of manganese bacteriopheophorbide as a potential contrast agent for magnetic resonance tomography

Bull Exp Biol Med. 2007 Apr;143(4):452-4. doi: 10.1007/s10517-007-0154-3.

Authors

I G Meerovich¹, A Brandis, G A Meerovich, A A Stratonnikov, P Bendel, N A Oborotova, A Shertz, A Yu Baryshnikov

Affiliation

¹ N. N. Blokhin National Cancer Research Center, Russian Academy of Medical Sciences, Moscow. meerovich@mail.ru

PMID: 18214298
DOI: 10.1007/s10517-007-0154-3

Abstract

The use of manganese bacteriopheophorbide characterized by a high relaxation capacity and selectively accumulating in the tumor as a contrast agent for magnetic resonance tomography significantly improves tumor contrasting against the background of normal tissues. The pharmacokinetics and selectivity of accumulation were studied by diffuse reflection spectroscopy.

MeSH terms

Animals
Bacteriochlorophylls / chemistry*
Bacteriochlorophylls / pharmacokinetics
Carcinoma, Ehrlich Tumor / diagnostic imaging
Carcinoma, Ehrlich Tumor / metabolism
Carcinoma, Ehrlich Tumor / pathology
Contrast Media / chemistry*
Contrast Media / pharmacokinetics
Magnetic Resonance Imaging / methods*
Manganese Compounds / chemistry*
Manganese Compounds / pharmacokinetics
Mice
Mice, Nude
Radionuclide Imaging

Substances

Bacteriochlorophylls
Contrast Media
Manganese Compounds