[Plasma and urine beta-thromboglobulin determination in the detection of thrombocyte hyperactivation in diabetic nephropathies]

Orv Hetil. 1991 May 26;132(21):1135-8, 1141.
[Article in Hungarian]

Abstract

Serum creatinine, immunoreactive serum and urine beta-2-microglobulin, plasma and urine thromboglobulin, plasma thromboxane-B2 levels and daily protein excretion were determinated in 61 insulin treated diabetic patients, comparing the different patient groups (complication free, nephropathy without azotaemia and nephropathy with azotaemia) with the control subjects. In the groups of all diabetic patients plasma and urine beta-thromboglobulin and plasma thromboxane-B2 levels were higher that in the controls. There was a positive significant correlation between urine beta-thromboglobulin and beta-2-microglobulin in the group without complication, and between the plasma beta thromboglobulin and beta-2-microglobulin, and plasma beta thromboglobulin and thromboxane levels in the diabetic group with azotaemia. In contradiction to some previous assumptions, the increased level of plasma beta-thromboglobulin reflects a real platelet hyperactivation also in patients with diabetic nephropathy. At the same time urine beta-thromboglobulin also increases. Determination of urine beta-thromboglobulin is more simple with less possibility of methodological error.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Blood Platelets
  • Diabetes Mellitus, Type 1 / blood*
  • Diabetes Mellitus, Type 1 / urine
  • Diabetic Nephropathies / blood*
  • Diabetic Nephropathies / urine
  • Humans
  • Proteinuria / diagnosis
  • Thromboxane B2 / blood
  • beta 2-Microglobulin / analysis
  • beta-Thromboglobulin / analysis*
  • beta-Thromboglobulin / urine

Substances

  • beta 2-Microglobulin
  • beta-Thromboglobulin
  • Thromboxane B2