CHIPping away at base excision repair

Robert W Sobol

doi:10.1016/j.molcel.2008.02.004

CHIPping away at base excision repair

Mol Cell. 2008 Feb 29;29(4):413-5. doi: 10.1016/j.molcel.2008.02.004.

Author

Robert W Sobol¹

Affiliation

¹ Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, PA 15213-1863, USA. rws9@pitt.edu

PMID: 18313379
DOI: 10.1016/j.molcel.2008.02.004

Abstract

In this issue of Molecular Cell, Parsons et al. (2008) report that the E3 ubiquitin ligase CHIP regulates the stability of the base excision repair (BER) proteins XRCC1 and DNA Pol beta, adding a new level of regulation for BER.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
DNA Damage
DNA Polymerase beta / genetics
DNA Polymerase beta / metabolism
DNA Repair*
DNA-Binding Proteins / genetics
DNA-Binding Proteins / metabolism
Humans
Macromolecular Substances / metabolism
Protein Processing, Post-Translational
Ubiquitin-Protein Ligases / genetics
Ubiquitin-Protein Ligases / metabolism*
X-ray Repair Cross Complementing Protein 1

Substances

DNA-Binding Proteins
Macromolecular Substances
X-ray Repair Cross Complementing Protein 1
XRCC1 protein, human
STUB1 protein, human
Ubiquitin-Protein Ligases
DNA Polymerase beta