Shortening of cardiac action potential duration near an insulating boundary

Math Med Biol. 2008 Mar;25(1):21-36. doi: 10.1093/imammb/dqn002. Epub 2008 Mar 14.

Abstract

It is known, from both experiments and simulations, that cardiac action potentials are shortened near a non-conducting boundary. In the present paper, this effect is studied in a simple, two-current ionic model, with propagation restricted to a 1D fibre. An asymptotic approximation for the dependence of action potential duration on distance to the boundary is derived. This estimate agrees well with simulations.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Action Potentials
  • Animals
  • Anura
  • Computer Simulation
  • Electrophysiology
  • Heart / physiology*
  • Models, Cardiovascular*
  • Myocardial Contraction