Aspergillus nidulans natural product biosynthesis is regulated by mpkB, a putative pheromone response mitogen-activated protein kinase

Appl Environ Microbiol. 2008 Jun;74(11):3596-600. doi: 10.1128/AEM.02842-07. Epub 2008 Mar 31.

Abstract

The Aspergillus nidulans putative mitogen-activated protein kinase encoded by mpkB has a role in natural product biosynthesis. An mpkB mutant exhibited a decrease in sterigmatocystin gene expression and low mycotoxin levels. The mutation also affected the expression of genes involved in penicillin and terrequinone A synthesis. mpkB was necessary for normal expression of laeA, which has been found to regulate secondary metabolism gene clusters.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aspergillus nidulans / metabolism*
  • Biological Products / biosynthesis*
  • Gene Deletion
  • Gene Expression Profiling
  • Gene Expression Regulation, Fungal
  • Indoles / metabolism
  • Mitogen-Activated Protein Kinases / genetics
  • Mitogen-Activated Protein Kinases / metabolism*
  • Penicillins / biosynthesis
  • Pheromones / metabolism*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sterigmatocystin / biosynthesis

Substances

  • Biological Products
  • Indoles
  • Penicillins
  • Pheromones
  • terrequinone A
  • Sterigmatocystin
  • Mitogen-Activated Protein Kinases