Integrating host genomics with surveillance for invasive bacterial diseases

Emerg Infect Dis. 2008 Jul;14(7):1138-40. doi: 10.3201/eid1407.071287.

Abstract

We tested the feasibility of linking Active Bacterial Core surveillance, a prospective, population-based surveillance system for invasive bacterial disease, to a newborn dried blood spot (nDBS) repository. Using nDBS specimens, we resequenced CD46, putative host gene receptor for Neisseria meningitidis, and identified variants associated with susceptibility to this disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Case-Control Studies
  • Child, Preschool
  • Feasibility Studies
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Infant
  • Infant, Newborn
  • Membrane Cofactor Protein / genetics
  • Meningitis, Bacterial / diagnosis
  • Meningitis, Bacterial / genetics*
  • Neonatal Screening*
  • Polymorphism, Single Nucleotide / genetics*
  • Population Surveillance*
  • Retrospective Studies

Substances

  • CD46 protein, human
  • Membrane Cofactor Protein