First total synthesis of clausine L and pityriazole, a metabolite of the human pathogenic yeast Malassezia furfur

Org Biomol Chem. 2008 Jul 21;6(14):2481-3. doi: 10.1039/b805451g. Epub 2008 May 22.

Abstract

The first total synthesis of the alkaloid pityriazole is described using three consecutive palladium-catalyzed coupling reactions.

MeSH terms

  • Carbazoles / chemical synthesis*
  • Carbazoles / metabolism
  • Catalysis
  • Humans
  • Indoles / chemical synthesis*
  • Indoles / metabolism
  • Malassezia / metabolism*
  • Palladium / chemistry

Substances

  • Carbazoles
  • Indoles
  • clausine L
  • pityriazole
  • Palladium