Scaffold-hopping cascade yields potent inhibitors of 5-lipoxygenase

ChemMedChem. 2008 Oct;3(10):1535-8. doi: 10.1002/cmdc.200800153.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Asthmatic Agents / chemistry*
  • Anti-Asthmatic Agents / pharmacology
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / pharmacology
  • Cells, Cultured
  • Drug Design
  • Humans
  • Imidazoles / chemistry
  • Imidazoles / pharmacology
  • Inhibitory Concentration 50
  • Lipoxygenase Inhibitors* / chemistry*
  • Lipoxygenase Inhibitors* / pharmacology
  • Structure-Activity Relationship

Substances

  • Anti-Asthmatic Agents
  • Anti-Inflammatory Agents
  • Imidazoles
  • Lipoxygenase Inhibitors