Benzaldehyde derivatives from Eurotium rubrum, an endophytic fungus derived from the mangrove plant Hibiscus tiliaceus

Chem Pharm Bull (Tokyo). 2008 Sep;56(9):1282-5. doi: 10.1248/cpb.56.1282.

Abstract

Four new (1-4) and seven known (5-11) benzaldehyde derivatives were characterized from the liquid fermentation cultures of Eurotium rubrum, an endophytic fungus that was isolated from the inner tissue of stems of the mangrove plant Hibiscus tiliaceus. The structures of these compounds were determined by extensive analysis of their spectroscopic data. Among these metabolites, compound 1, which was named as eurotirumin, possesses a new carbon skeleton with a cyclopentabenzopyran ring system.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibiotics, Antineoplastic / isolation & purification*
  • Antibiotics, Antineoplastic / pharmacology*
  • Ascomycota / chemistry*
  • Benzaldehydes / isolation & purification*
  • Benzaldehydes / pharmacology*
  • Cell Line, Tumor
  • Chromatography, Thin Layer
  • Drug Screening Assays, Antitumor
  • Fermentation
  • Hibiscus / microbiology*
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mice
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrophotometry, Infrared
  • Tetrazolium Salts
  • Thiazoles

Substances

  • Antibiotics, Antineoplastic
  • Benzaldehydes
  • Tetrazolium Salts
  • Thiazoles
  • thiazolyl blue