Abstract
It is becoming increasingly clear that epigenetic modifications are critical factors in the regulation of gene expression. With regard to the nervous system, epigenetic alterations play a role in a diverse set of processes and have been implicated in a variety of disorders. Gaining a more complete understanding of the essential components and underlying mechanisms involved in epigenetic regulation could lead to novel treatments for a number of neurological and psychiatric conditions.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Brain Diseases / genetics*
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Brain Diseases / metabolism*
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Brain Diseases / physiopathology
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Chromatin / genetics
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Chromatin / metabolism
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DNA Methylation / genetics
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Epigenesis, Genetic / genetics*
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Gene Expression Regulation / genetics*
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Genetic Predisposition to Disease / genetics*
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Histone Deacetylase Inhibitors
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Histone Deacetylases / metabolism
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Histones / genetics
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Histones / metabolism
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Humans
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Nervous System / metabolism*
Substances
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Chromatin
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Histone Deacetylase Inhibitors
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Histones
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Histone Deacetylases