Interferon-gamma enhances PAF-acether production by stimulated human polymorphonuclear leucocytes

Scand J Immunol. 1991 May;33(5):575-8. doi: 10.1111/j.1365-3083.1991.tb02528.x.

Abstract

Human polymorphonuclear leucocytes (PMN) stimulated with either immune complexes (IC), phorbol myristate acetate (PMA) or N-formyl-methionyl-leucyl-phenylalanine (FMLP) generate platelet-activating factor (PAF-acether). The present study demonstrates that treatment of PMN with recombinant human interferon-gamma (IFN-gamma) significantly enhanced the production of PAF-acether by stimulated cells, in a concentration-dependent mode. On the contrary, alpha and beta IFN were completely unable to increase PAF-acether synthesis by stimulated PMN. The significance of these results is discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigen-Antibody Complex / physiology
  • Cells, Cultured
  • Humans
  • Interferon-gamma / pharmacology*
  • N-Formylmethionine Leucyl-Phenylalanine / pharmacology
  • Neutrophils / drug effects
  • Neutrophils / metabolism*
  • Platelet Activating Factor / biosynthesis*
  • Tetradecanoylphorbol Acetate / pharmacology

Substances

  • Antigen-Antibody Complex
  • Platelet Activating Factor
  • N-Formylmethionine Leucyl-Phenylalanine
  • Interferon-gamma
  • Tetradecanoylphorbol Acetate