Abstract
Two recent papers reported identification of a long-sought agrin coreceptor, Lrp4 (Kim et al. in Cell and Zhang et al. in Neuron). In this issue of Neuron, Linnoila et al. report the identification of a new player in the agrin-MuSK pathway, Tid1, which directly interacts with MuSK and is responsible for transducing signals from MuSK activation to AChR clustering, culminating in cross-linking to the subsynaptic cytoskeleton. These papers substantially reshape the agrin-MuSK-ACh hypothesis of neuromuscular synaptogenesis.
MeSH terms
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Agrin / metabolism*
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Animals
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HSP40 Heat-Shock Proteins / metabolism*
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Humans
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LDL-Receptor Related Proteins
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Mice
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Neuromuscular Junction / embryology*
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Neuromuscular Junction / metabolism*
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Neuromuscular Junction / ultrastructure
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Receptor Aggregation / physiology
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Receptor Protein-Tyrosine Kinases / metabolism
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Receptors, Cholinergic / metabolism
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Receptors, LDL / metabolism*
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Signal Transduction / physiology
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Synapses / metabolism*
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Synapses / ultrastructure
Substances
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Agrin
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Dnaja3 protein, mouse
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HSP40 Heat-Shock Proteins
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LDL-Receptor Related Proteins
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Lrp4 protein, mouse
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Receptors, Cholinergic
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Receptors, LDL
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MuSK protein, mouse
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Receptor Protein-Tyrosine Kinases